Organic Chemistry: Current Research
Open Access

Potential metallopharmaceutical agents; synthesis, spectroscopic characterization and antiproliferative study of novel metal complexes of tetra thiosemicarbazon ligand

10^th European Organic Chemistry Congress

March 21-22, 2019 | Rome, Italy

Abdou S El-Tabl, Moshira M. Abd-El Wahed, Mohamed Abdou Saad and Abdelhaleam A. Aly

El-Menoufia University, Egypt

Posters & Accepted Abstracts: Organic Chem Curr Res

Abstract :

There has been much interesting in the development a new tetrathiosemicarbazone ligand and its Fe(III), Co(II), Ni(II), Cu(II), Zn(II), Cd(II), Pb(II), Al(III), Ca(II), Ba(II), Sr(II), Mg(II), and Ag(I), complexes . Complexes have been characterized by elemental analysis, IR, UV-Vis spectra , 1H-NMR spectra, Mass spectra, Magnetic moments, Conductances, Thermal analyses (DTA and TGA) and ESR measurements The spectral data show that the ligand behaves a neutral or dibasic –octadentate type. Molar conductances in DMF solution indicate non-electrolytic nature of the complexes. The complexes show anisotropic or isotropic type (dx2-y2) ground state with considerable covalent bond character. To study the cytotoxicity of the ligand and some of its metal complexes against human liver cancer cell (HePG-2 cell line). The cells were dosed with the complexes at varying concentrations and cell viability was measured by sulfo-rhodamine-B stain (SRB) method. The compounds show marked antiproliferative effect compared with a standard drug (vinblastine).