Post-menapousal hirsutism due to ovarian theca-cell hyperplasia and Leydig cell tumour: A case report
Endocrinology & Metabolic Syndrome

Endocrinology & Metabolic Syndrome
Open Access

ISSN: 2161-1017

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Post-menapousal hirsutism due to ovarian theca-cell hyperplasia and Leydig cell tumour: A case report

Joint Event on 11th World Congress on Endocrinology and Metabolic Disorders and 2nd International Conference on Thyroid & Pregnancy

September 03-04, 2018 Auckland, New Zealand

Demet Corapcioglu

Ankrar University Hospital, Turkey

Posters & Accepted Abstracts: Endocrinol Metab Syndr

Abstract :

Introduction: Hirsutism is defined as the presence of terminal coarse hairs in females in a male-like distribution. It affects around 5-10% of women, increasing with age because of low estrogen and relatively high androgen levels, especially in postmenapousal period. Case: A seventy five years old female admitted to endocrinology department with complaining of hair loss and hirsutism within one year. Her past medical history consisted of type 2 diabetes, coronoary artery disease, hypertension and depression. She was obese with body mass index 34 kg/m2, and she had temporal balding, coarseness of fascial features, hypertrichosis of chin, back, buttock and genital region. She had also virilization with the increase in muscle mass, mild clitoromegaly, hoarseness of voice, and she complanied about depressed mood. Patient serum gonadotropin concentrations were in the post-menopausal ranges but serum testosteron level was as high as 435 ng/dL (10-75). Free testosteron level was also high as 3.6 pg/mL (0.2-3), and serum DHEA-S level was normal as 33 mcg/dL (25-460). For excluding any ovarian pathtology, abdomino-pelvic MRI was done. It revealed atrophic ovaries and a 2.5 cm mass at right adrenal gland compatible with an adenoma. Adrenal adenoma was hormonally inactive. To distinguish whether adrenal adenoma produces any testosteron or its?? metabolite, the patient was underwent Adrenal Venous Sampling (AVP). AVP was not diagnostic because of inability to cannulatte right adrenal vein. On this occasion, oopherectomy and unilateral adrenalectomy was planned. Pathology report was as follows: ??Non-specific adneal adenoma, theca-cell hyperplasia in right ovary and Leydig cell tumour in left ovary?. After surgery patient??s testosteron level declined immediately, and after six months, she was free of her complaints. Discussion: There is a dramatic decrease in adrenal androgens with aging, and changes in ovarian androgen secretion after menopause are far less dramatic. Even if patient had radiologically normal ovaries theca-cell hyperplasia and ovarian tumours must be kept in mind especially in patients with high testosteron levels, because adrenal androgens are less responsible for severe female hirsutism in elderly.

Biography :

Demet Corapcioglu has completed her PhD at the age of 23 years from Ankarra University and postdoctoral studies from Ankara University Faculty of Medicine. She is the director of Endocrinology and Matabolic Disease Department, İnternal Medicine, Ankara University Hospital, She has published more than 25 papers in reputed journals she has been member of ECEand ETA.

E-mail: [email protected]