Porcine models for toxicology and pharmaceutical research | 50880
Journal of Clinical Toxicology

Journal of Clinical Toxicology
Open Access

ISSN: 2161-0495

+44 1478 350008

Porcine models for toxicology and pharmaceutical research

International Toxicology Summit & Expo

November 26-28, 2012 Hilton San Antonio Airport, USA

M. Michael Swindle

Scientific Tracks Abstracts: J Clinic Toxicol

Abstract :

S wine share many anatomic and physiologic characteristics with humans which make them one of the primary translational research models. In particular swine display similar physiology to humans for the cardiovascular, digestive, urologic and dermatologic systems. The characteristics which make them an applicable model for biomedical research also make them a suitable model for many aspects of toxicological studies. Reactions of the heart and vascular system to test substances are closely related to similar reactions in humans. Swine are true omnivores and process ingested substances in a similar fashion. The cytochrome P-450 system has both similarities and differences. They have similar oxidative biotransformation, high glucuronidation, high acetylation and low sulfation activities. Pig skin is used for transdermal toxicology studies because of similar anatomy, cellular turnover time, permeability, and absorption characteristics. The multirenculate, multipappilate kidneys are more similar to humans in anatomy and physiology than other common lab animals. In addition fetal pharmacology and toxicology studies have been performed in this species because of the transplacental passage characteristics of test substances. This species does require unique approaches to chronic catheterization and oral administration techniques which will be detailed

Biography :

M. Michael Swindle graduated from Texas A&M University with a doctorate in veterinary medicine (DVM, 1969). He is board certified in lab animal medicine both in the US and Europe (ACLAM and ECLAM). Upon completion of a residency in comparative medicine and pathobiology at the Johns Hopkins University School of Medicine he was appointed as a faculty member in the Departments of Surgery and Comparative Medicine. Since 1985 he has served as Professor and Chairman Department of Comparative Medicine. He has devoted a major portion of his career to development of domestic swine and minipigs as models in biomedical research and has >300 publications and professional presentations. He has received research awards from the American Heart Association, the American College of Lab Animal Medicine, the American Society of Lab Animal Practitioners and the Academy of Surgical Research. He was honored as an Outstanding Alumnus of Texas A&M University in 2010