Journal of Pharmaceutical Care & Health Systems
Open Access
ISSN: 2376-0419
+44 1300 500008
ISSN: 2376-0419
+44 1300 500008
Charu Tyagi, Lomas Tomar, Yahya E Choonara and Viness Pillay
University of the Witwatersrand, South Africa
Posters-Accepted Abstracts: J Pharma Care Health Sys
In the present study drug-loaded electrospun nanofiber scaffold were prepared and characterized for their potential application as wound dressing material. A copolymeric blend of poly (lactic-co-glycolic acid) (PLGA) and elastin was electrospun in Hexa Fluoro Iso Propanol (HFIP) at the concentrations of 10%w/v. Different ratios of PLGA and elastin were scrutinized for apposite electro spinning efficiency and results with the optimal ratio of 4:1 are reported here. The drug of choice, which was erythromycin, was added as 2% of the total elctrospinning polymer solution. Physicochemical and physicomechanical properties of the developed nanofiber scaffold were analysed through FTIR, SEM, DSC, TGA, rheology, moisture content and nanotensile testing to ascertain the required properties of polymers within scaffolds. Antibacterial effectiveness of the drug-loaded scaffold was studied using the pour plate/disc method by measuring the zone of inhibition from the edge of the drug-loaded scaffold. The scaffold discs were tested against E. coli, E. faecalis, S. aureus and M. catarrhalis while the erythromycin disc and non-drug loaded scaffold were employed as controls. Optimized scaffold presented a zone of inhibition because of the sustained and controlled drug release from the scaffold discs. Scaffold characterization and evaluation results are supportive of its potential as an effective wound healing and dressing material.
Email: charu.tyagi@wits.ac.za