Biochemistry & Pharmacology: Open Access
Open Access
ISSN: 2167-0501
ISSN: 2167-0501
Ngoutane Mfopa Alvine
Accepted Abstracts: Biochem & Pharmacol
Malaria remains the most dangerous parasitic infection in many tropical and subtropical countries and therefore is a major public health problem concern. In spite of the availability of artemisinin-based combination therapies resistance has been reported. Then, the discovery and development of new antimalarials drugs of natural origin are urgently needed. Our project will aim to investigate the antimalarials properties of plant extract from Polyalthia suaveolens and Polyalthia oliveri (Annonaceae family). Collected materials will be extracted by maceration in 95% ethanol and partitioned using an organic solvent system in order to obtain acetogenin-enriched extracts (interest extracts). These extracts obtained will be purified to isolate and to characterize the pure coumpounds using colomn chromatography and spectroscopic method. Then the evaluation of antiplasmodial activity in continuous culture against Plasmodium falciparum strain resistant to chloriquine and other antimalarial drugs were performed. Active fractions will be assessed for their in vivo test in Swiss albino mice against malarial strain parasite (Plasmodium berghei) with the classical 4-day suppressive test. Finally the possible potentiation of molecules with current antimalarials drugs will be carried out and cytotoxic effect on human hepatoma cell in culture.