Endocrinology & Metabolic Syndrome
Open Access
ISSN: 2161-1017
ISSN: 2161-1017
Laaraib Nawaz
Government College University Faisalabad, Pakistan
Scientific Tracks Abstracts: Endocrinol Metab Syndr
Diabetes mellitus is associated with adverse structural and cardiac remodeling, ultimately leading to heart failure (HF). Available hypoglycemic therapies are unable to prevent or reverse cardiac remodeling thus possibility of natural products with potential to reverse cardiac remodeling should be explored. In this context, current study is aimed at exploring the potential of Pheonix dactylifera (PD) extract in attenuation of cardiac remodeling in diabetic cardiomyopathy rats. For this purpose, Wistar albino rats (N=16; age 2±1 weeks) were bred and kept at standard conditions. Normal control (NC; n=4) fed with normal chow diet and water ad libitum while others (n=12) were fed with high fat diet, followed by STZ injection. Hyperglycemic rats (FBG�150mg/dl at 72hrs) were divided into 3 groups: positive control (DCM), standard control of metformin (DCM+Met), extract treated group (DCM+PD). Serum glucolipid, myocardial enzymes, oxidative stress markers were evaluated at day 15 and 25 with gene expression and histopathology of pancreas and ventricle. After statistical analyses, our findings revealed PD extract restored glucolipid alterations, and decreased oxidative stress as compared to DCM group showing hyperglycemia, increased oxidative stress and resultant elevated myocardial enzymes with distorted structure of myocardium. Moreover, PD extract improved insulin sensitivity by upregulating insulin signaling pathway and suppressed ventricle inflammatory and fibrotic mediators consequently leading to normalized myocardium architecture. Thus it is concluded that PD extract has the potential to attenuate adverse cardiac remodeling associated with diabetes by regulating inflammatory markers.
Laaraib Nawaz is currently affiliated with the Health Biology Laboratory in the Department of Physiology, Faculty of Life Sciences, at Government College University Faisalabad, Punjab, Pakistan. Her research focuses on exploring natural therapeutic interventions for chronic diseases, with a particular emphasis on cardiovascular complications associated with diabetes.