Pharmacodynamic studies of Self-Nanoemulsifying Drug Delivery Sys | 8192
Journal of Developing Drugs

Journal of Developing Drugs
Open Access

ISSN: 2329-6631

+44 1478 350008

Pharmacodynamic studies of Self-Nanoemulsifying Drug Delivery Systems for the oral administration of Rosuvastatin calcium

International Conference and Expo on Generic Drug Market & Contract Manufacturing

November 07-09, 2016 Barcelona, Spain

E Gundogdu

Ege University, Turkey

Posters & Accepted Abstracts: J Develop Drugs

Abstract :

Self-Nanoemulsifying Drug Delivery Systems (SNEDDs) are mixtures of oils, surfactants and co-surfactants. Several studies have shown that compounds which have low permeability are better absorbed when administrated in SNEDDs. SNEDDs possess have high solubilization capacity, more stable physicochemical properties and easier preparation process. Rosuvastatin (RS) is a synthetic lipid-lowering agent and the oral bioavailability of RS is 20% because of low aqueous solubility due to its crystalline nature and is extensively metabolized by liver via oxidation, lactonization, and glucuronidation. Among these approaches, SNEDDs were chosen to evaluate poorly absorbed drug from the gastrointestinal tract such as RS after oral delivery. After development of RS-SNEDDs, in vivo pharmacodynamic studies were done. Two groups of Yorkshire pigs were used and cross design was applied to perform study. Four (4) pigs were allocated to each group. SNEDDS and commercial formulations were administered at the same doses (20 mg/kg) during 7 days. At the beginning and end of study, blood samples were withdrawn from earing vein and analyzed biochemically (SGPT; SGOT, HDL, LDL, urea, creatinine, triglyceride). According to the obtained results, RS-SNEDDS is as safe as the commercial RS. Furthermore, RS-SNEDDS is more efficient than the commercial formulation. These findings confirmed similar safety profile of SNEDD formulation with traditional pharmaceutics formulation of Rosuvastatin.