Drug Designing: Open Access
Open Access
ISSN: 2169-0138
ISSN: 2169-0138
Samar Mansour, Sara S Naguib and Rania M Hathout
German University in Cairo, Egypt
Ain Shams University, Egypt
Posters & Accepted Abstracts: Drug Des
The work in this study comprised the use of different hybrids of GRAS (Generally regarded as safe) oils and surfactants in order to develop and optimize novel acetazolamide entrapped-vesicular systems aiming at improving its ocular delivery and reaching better therapeutic outcomes in the treatment of glaucoma. Accordingly, the phospholipid/cholesterol bilayer of the vesicles was enriched with hybrids of Tween 80, Labrasol, Transcutol and Labrafac lipophile WL in different masses and proportions according to a mixture design. Three models were generated comprising three responses; particles size, percentage of entrapment efficiency and amount of drug released after 24 hours (Q24h). The results demonstrated the ability of the used penetration enhancer��?s hybrids in modulating the three responses with respect to the conventional liposomes. Transmission electron microscope was used to characterize the selected formulations. Moreover, sterilization of the selected formulations was carried out using gamma radiation and the effect of gamma radiations on entrapment, particle size and in vitro were studied. The selected sterilized formulations were tested in-vivo on the eyes of albino rabbits in order to evaluate the efficiency of the novel delivery systems on the intra-ocular pressure reduction (IOP) compared to drug solution and the conventional liposomes. The novel formulations proved their efficiency in reducing the IOP to lower values compared to the conventional liposomes which pose new successful platform for ocular delivery of Acetazolamide and other anti-glaucoma drug analogues.
Email: samar.mansour@guc.edu.eg