Oncologic impact of postoperative delta-neutrophil index in pancreatic cancer
Immunotherapy: Open Access

Immunotherapy: Open Access
Open Access

ISSN: 2471-9552

Oncologic impact of postoperative delta-neutrophil index in pancreatic cancer

2nd International Conference on Tumor & Cancer Immunology and Immunotherapy

July 17-18, 2017 Chicago, USA

Sung Hwan Lee

Yonsei University College of Medicine, Korea

Scientific Tracks Abstracts: Immunotherapy (Los Angel)

Abstract :

Background: Major cancer surgery can cause surgical stress and disturbs the immune system. The oncologic impact of perioperative immune disturbance is not yet known. Methods: From December 2009 to December 2013, totally 154 patients who underwent pancreatic resection for pancreatic ductal adenocarcinoma were enrolled into this study. Perioperative leukocyte and lymphocyte counts assessed by an automated blood cell analyzer were obtained from institutional database. Clinicopathologic factors and survival data were identified from medical record. Results: Immature granulocytes counted by delta neutrophil index (DNI) were significantly correlated with oncologic outcomes after curative resection of pancreatic ductal adenocarcinoma. The highest value, elevation period, and bimodality of DNI value were statistically significant predictive factors for cancer recurrence after pancreatic resection. Conclusions: Postoperative DNI predicts the tumor recurrence after resection of pancreatic cancer. Well-designed clinical and translational researches for perioperative immune disturbance are mandatory for revealing crucial concepts for tumor immunology in veiled therapeutic viewpoint.

Biography :

Sung Hwan Lee is a Clinical & Research Fellow in Department of Surgery, Yonsei University College of Medicine, Republic of Korea. His Academic Interests include Hepatobiliary and pancreatic surgery / Surgical oncology for pancreatic cancer / Molecular Imaging by two-photon microscopy Pancreatic cancer microenvironment / Cancer metabolism

Email: [email protected]