Drug Designing: Open Access
Open Access

Novel folate-modified lipid-polymer hybrid nanoparticles for targeted paclitaxel delivery

16^th International Conference and Exhibition on Pharmaceutical Formulations

July 26-27, 2018 | Rome, Italy

Linhua Zhang, Fan Fan, Yu Qin and Dunwan Zhu

Peking Union Medical College ��? CAMS, China

Scientific Tracks Abstracts: Drug Des

Abstract :

Lipid-polymer hybrid nanoparticles (LPNPs) are polymeric nanoparticles enveloped by lipid layers that combine the highly biocompatible nature of lipids with the structural integrity afforded by polymeric nanoparticles. In this study, a novel lipid-polymer hybrid nano-carrier was synthesized that composed of folate (as targeting ligand), DSPE-PEG2000 (as lipidshell) and PCL-PEG-PCL (as self-assembled core). Sustained, controlled and targeted delivery of the anticancer drug PTX (Paclitaxel) from the hybrid nanoparticles was successfully demonstrated both in vitro and in vivo. The PTX-loaded FLPNPs (folic acid modified lipid-shell and polymer-core nanoparticles) were prepared using thin-film hydration and ultrasonic dispersion method. TEM (Transmision electron microscopy) image confirmed that the FLPNPs exhibited homogeneous spherical shapes with apparent hydrophobic polymer core and lipid monolayer shell on the surface. CLSM (confocal laser scanning microscopy) image further confirmed the â�?�?core-shell-shellâ�? structure of the FLPNPs, where the inner lipid-shell was labeled with rhodamine-PE. Nile Red-loaded FLPNPs showed higher efficient endocytosis abilities in FR-overexpressing EMT6 cells when compared to nontargeted LPNPs. In BALB/c mice bearing EMT6 tumors, PTX-loaded FLPNPs showed similar antitumor efficacy but low toxicity compared to Taxol�?® via intratumoral chemotherapy. More importantly, PTX-loaded FLPNPs exhibited superior therapeutic efficiency than the PTX-loaded LPNPs, confirming the effective cellular accumulation and anticancer activity of folate targeted NPs via receptor-mediated endocytosis. These findings indicated that the PTX loaded- FLPNPs with mixed lipid monolayer shell and biodegradable polymer core would be a promising nanosized drug formulation for tumor-targeted therapy.

Biography :

Linhua Zhang has completed her PhD from Peking Union Medical College in 2015. She focus her work on developing novel polymeric materials for anticancer drugs, therapeatic genes and immunomodulatory molecules delivery. She is a Full Professor at the Institute of Biomedical Engineering, Peking Union Medical College and Chinese Academy of Medical Sciences. She has published more than 30 papers in reputed journals. .

E-mail: zhanglinhua@bme.pumc.edu.cn