Novel biodegradable MAACP / n-HA (multi-amino-acid copolymer/nano | 497
Rheumatology: Current Research

Rheumatology: Current Research
Open Access

ISSN: 2161-1149 (Printed)


Novel biodegradable MAACP / n-HA (multi-amino-acid copolymer/nano-hydroxyapatite) composite artificial lamina following spinal surgery for lamina reconstruction

International Conference and Exhibition on Orthopedics & Rheumatology

August 13-15, 2012 Hilton Chicago/Northbrook, USA

Chaoliang Lv, Zhongjie Zhou, Yueming Song, Limin Liu, Hong Duan, Chongqi Tu and Fuxing Pei

Posters: Rheumatology & Orthopedics

Abstract :

Background Context: Posterior laminectomy is an effective surgical procedure in spinal surgery. After laminectomy, the adhesion of postoperative scar tissue to surgically exposed dura and, occasionally, to nerve roots has been implicated as a possible cause of failed back surgery syndrome (FBSS). The establishment of a barrier between scar tissue and dura is an effective way to prevent scar adhesions. The soft and sticky material is very difficult to effectively prevent epidural adhesions and oppression. Therefore, some authors suggested hard material can supply enough strength to prevent scar adhesions and oppression. Purpose: To evaluate the efficacy of novel biodegradable MAACP / n-HA composite artificial lamina for the prevention of postlaminectomy adhesions and lamina reconstruction. Study Design/Setting: An animal model of Cervical laminectomy in goats was used .Cervical 4 was removed by laminectomy. MAACP / n-HA composite artificial lamina was inserted in the test group, and in the control group, the incision was closed directly without a polymer artificial lamina implantation. The efficiency of the copolymer during repair and reconstruction of the goats? vertebra was tested by using X-ray, CT scanning, MRI, SEM, histological and biomechanical measurements. Patient Sample: Goats Outcome Measures : X-ray, CT, MRI, SEM, histological examinations. Methods: The goats were randomly divided into three groups: an experimental group consisting of twelve goats that underwent cervical 4 laminectomies, followed by MAACP / n-HA composite artificial lamina implantations; a control group of nine goats whose cervical 4 vertebra plate were removed; and a normal group of three goats that did not receive any operations or treatments. On weeks 4, 12 and 24, two goats, two goats, three goats in the test group and two, two, two in the control group were selected using X-ray, CT ,MRI subsequently killed for histological examinations and SEM(scanning electronic microscope). On week 24, the adhesion level of scar tissue was examined according to Rydell?s degree of adhesion criteria.And,3 in the test group,3 in the control group,3 in the normal group goats were acquired on week 24, and biomechanical measurements were carried out. Results: In the experimental group, the artificial lamina refrained from shifting, and no dural adhesion pressure was observed and, new goat cervical natural bone formed in the defect and bony spinal canal had been rebuilt. In contrast, in the control group, fibrous scar tissue filled the defect and the scar tissue continued to exert pressure on the dura. Conclusions: Artificial lamina could prevent the epidural adhesions surrounding the defect and promote effectively bone tissue repair and new bone formation.