Journal of Clinical Toxicology
Open Access
ISSN: 2161-0495
+44 1478 350008
ISSN: 2161-0495
+44 1478 350008
Yu Jie and Xu Jie
Zunyi Medical University, P R China
Scientific Tracks Abstracts: J Clinic Toxicol
Exposure to environmental endocrine disruptors (EEDs) contributes to the pathogenesis of many metabolic disorders. Here, we have analyzed the effect of the EED-nonylphenol (NP) in the promotion of non-alcoholic fatty liver disease (NAFLD) in rats fed high sucrose-high fat diet (HSHFD). Fifty Sprague-Dawley rats were divided into five groups: controls fed a normal diet (C-ND); HSHFD-fed controls (C-HSHFD); and rats fed a HSHFD combined with NP at doses of 0.02 �?¼g/kg/day (NPL-HSHFD), 0.2 �?¼g/kg/day (NP-M-HSHFD), and 2 �?¼g/kg/day (NP-H-HSHFD). Subchronic exposure to NP coupled with HSHFD increased daily water and food intake (p<0.05), hepatic echogenicity and oblique liver diameter (p<0.05), and plasma levels of alanine aminotransferase, aspartate aminotransferase, total cholesterol, triglycerides, and low density lipoprotein cholesterol (p<0.05). Combined exposure to NP and HSHFD induced macrovesicular steatosis with dilation and congestion of the central vein, liver inflammatory cell infiltration, and expression of genes regulating lipid metabolism, SREBP-1C, FAS, and Ucp2. These results demonstrate that NP aggravates NAFLD in HSHFD-treated rats by up-regulating lipogenic genes, and that HSHFD increases the toxic effects of NP. Thus subchronic NP exposure may lead to NAFLD, especially when combined with a high-sucrose/high-fat diet.
Recent Publications
1. Yu Jie et al. (2018) Protective effects of Chinese Fenggang zinc selenium tea on metabolic syndrome in high-sucrosehigh-fat diet-induced obese rats. Scientific Reports. 8(1):3528.
2. Jie Yu et al. (2018) The adverse effects of chronic low-dose exposure to nonylphenol on type 2 diabetes mellitus in high sucrose-high fat diet-treated rats. Islets. 10(1):1-9.
3. Jie Yu et al. (2017) Adverse effects of chronic exposure to nonylphenol on non-alcoholic fatty liver disease in male rats. PloS One. 12(7): e0180218.
4. Yu Jie et al. (2017) Pollution by Nonylphenol in river, tap water, and aquatic in an acid rain-plagued city in southwest China. International Journal of Environmental Health Research. 27(3):179-190.
5. Jing Yang et al. (2017) The adverse effects of perinatal exposure to nonylphenol on carbohydrate metabolism in male offspring rats. International Journal of Environmental Health Research. 27(5):368-376.
Yu Jie has his expertise in Environmental Toxicology. His most recent researches focus on the impact of environmental endocrine disruptors on endocrine metabolism disorder, neurotic depression and its mechanisms.
E-mail: xujie360@hotmail.com