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New synthetic route for preparation of Cis (-) nucleosides | 37718
Organic Chemistry: Current Research

Organic Chemistry: Current Research
Open Access

ISSN: 2161-0401

+44 1478 350008

New synthetic route for preparation of Cis (-) nucleosides


3rd International Conference on Organic and Inorganic Chemistry

July 17-19, 2017 Chicago, USA

Devender Mandala and Paul Watts

Nelson Mandela Metropolitan University, South Africa

Posters & Accepted Abstracts: Organic Chem Curr Res

Abstract :

Cis-nucleoside derivatives lamivudine (3TC) and emtricitabine (FTC) are useful in the treatment of retroviral infections caused by human immune deficiency virus (HIV), Hepatitis B virus (HBV) and Human T-Lymotropoic virus (HTLV). Lamivudine and emtricitabine are potent nucleoside analogue reverse transcriptase inhibitors (nRTI). These two drugs are synthesized by a four-stage process from the starting materials: Menthyl glyoxylate hydrate and 1,4-dithane-2,5-diol. All reagents and intermediates have been tested satisfactorily. Pharmaceutical development has been adequately described and also it has been shown as the most thermodynamically stable form. Although there are several different methods reported for the synthesis of lamivudine and emtricitabine as a single enantiomer, we required an efficient route, which was suitable for largescale synthesis to support the development of these compounds. In this process, we successfully prepared the intermediates of lamivudine and emtricitabine without using any solvents and catalyst, thus promoting the green synthesis.

Biography :

Email: devenderreddymandala@gmail.com

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