Clinical & Experimental Cardiology
Open Access
ISSN: 2155-9880
+44 1300 500008
ISSN: 2155-9880
+44 1300 500008
Miguel Maluf
Posters-Accepted Abstracts: J Clin Exp Cardiolog
Introduction: The biological cardiac prostheses still not the ideal replacement valve for pediatric patients due to early calcification and exposing the patient to multiple valve replacements. Objectives: Develop a prototype expandable stent valve polyurethane for transcatheter implantation in sheep, undergoing expansion during the postoperative follow-up . The diameter of the expandable stent valve may be accomplished through the use of balloon catheter. Material / Methods: Prototype: The first step: will be built expandable stent valve chrome cobalt, with a diameter of 22 mm. This step will be performed in collaboration between Universidade Federal de Sao Paulo (UNIFESP) and Bentley - InnoMed - Germany. In the second step: is constructed of 3 polyurethane leaflets, at UNIFESP Lab. The third step: Ligation of the sent valve in the catheter balloon, after hydrodynamic studies and submitted to valve clipping, reducing the diameter of 22 mm to 4.2 mm (13 FR). The sterilization is performed by gamma radiation. . Experimental Surgery: The prosthesis was implanted in the pulmonary position in 14 sheep 4-6 months old and weighing 20 to 30 kg, using a transcatheter technique. In seven sheep will be expanded up to 22mm and in the remaining 7, expanded up to 18mm in diameter. Results: Follow-up after surgery. All experimental animals will be treated with antiplatelet agents. The period of postoperative follow-up will be 6 months. In the third month after surgery will undergo to Doppler echocardiography. The 7 sheep with stent diameter of 18 mm, will undergo dilation using balloon catheter. In the sixth month postoperatively, the sheep will be subjected to euthanasia and explantation of the prosthesis for histopathology. Discussion: Experimental studies valve polyurethane published showed good hemodynamic performance, low incidence of calcification and fatigue resistant. The expandable stent has advantages because you can change the diameter of the stent, using a balloon catheter, after the development of the child. Conclusion: The valves can be expanded with the growth of the patient, reducing the need for surgery for valve replacement and improving the quality of life of patients.