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New features of intracellular parasite elimination in the presenc | 3985
Drug Designing: Open Access

Drug Designing: Open Access
Open Access

ISSN: 2169-0138

+44 1223 790975

New features of intracellular parasite elimination in the presence of new anti-proliferative compounds: New insights to drug development


International Conference and Expo on Drug Discovery & Designing

August 11-13, 2015 Frankfurt, Germany

La�?­s Pessanha de Carvalho

Posters-Accepted Abstracts: Drug Des

Abstract :

A wide variety of microorganisms develops and replicate on intracellular environment, being able to disseminate through
the organism after these events. For this purpose, the pathogen avoid or evade many microbicide mechanism involved in
cellular defense. The standard model for drug development includes the direct interaction between drug and target, but when it
comes to intracellular pathogen, this strategy has been inefficient. Considering that the intracellular environment protects the
pathogen, the chemotherapy against it is inefficacious or limited and can cause diverse side effects to host. Therefore, in the last
years, our group has demonstrated the activity of a series of semicarbazones and derivatives compounds against intracellular
parasites. The main objective of these studies was to elucidate the aspects of the parasite elimination; even it is present in either
cytoplasm or vacuole, after drug administration. The use of anti-proliferative compounds, whose activity is mainly the blockage
of DNA synthesis, is a distinct concept of chemotherapy. The use of compounds belonging to semicarbazones and derivatives
such as thiosemicarbazones and thiazolidinones has been efficient on elimination of Leishmania amazonensis, Trypanosoma
cruzi and Toxoplasma gondii at low concentrations. Initially these compounds arrest the parasite proliferation so the host cell
becomes able to restore its microbicide mechanisms without show cytotoxic effects. Analyses through microscopy techniques
suggest that a series of cellular events such as intracellular digestion, autophagy and apoptosis are related to parasite elimination.

Biography :

Laís Pessanha de Carvalho has finished her Master degree in 2015, at age of 24 at Universidade Estadual do Norte Fluminense Darcy Ribeiro. Her studies include cellular
aspects of elimination of intracellular parasites in presence of synthetic and natural compounds.

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