Organic Chemistry: Current Research
Open Access

New diphenyl ether hydrazone metal complexes as promising future treatment for hepatocellular carcinoma

10^th European Organic Chemistry Congress

March 21-22, 2019 | Rome, Italy

Abdou S El-Tabl, Moshira M Abd-El Wahed, Mohamed Abdo Saad and Eman Shawky nofal

El-Menoufia University-Faculty of Science, Egypt El-Menoufia University-Faculty of Medicine, Egypt

Posters & Accepted Abstracts: Organic Chem Curr Res

Abstract :

Novel metal (II) complexes of diphenyl ether hydrazone have been synthesized and spectroscopically characterized using IR, UV-Vis spectra, magnetic moments,1H NMR, mass spectra, molar conductance, and ESR measurements as well as Thermal analyses (DTA and TGA). The complexes adopt distorted octahedral geometry. Molar conductance in DMF solution indicates the non-ionic nature of the complexes. The ESR spectra of solid Cu (II) complexes showed g11>gâ�?´>ge. The cytotoxicity of the ligand and its metal complexes showed potent cytotoxicity effect against growth of human liver cancer HepG2 cell line compared to the clinical used Sorafenib (Nexavar). The results show that, some complexes recorded high cytotoxicity against HEPG-2 cell lines regarding to IC50. Also, the cytotoxicity was found to be concentration dependent. The complexes are very promising showing high activity against HepG2.