Necrostatin-1 counteracts neuronal cell loss induced by aluminum | 51043
Journal of Clinical Toxicology

Journal of Clinical Toxicology
Open Access

ISSN: 2161-0495

Necrostatin-1 counteracts neuronal cell loss induced by aluminum

2nd International Summit on Toxicology

October 07-09, 2013 Hampton Inn Tropicana, Las Vegas, NV, USA

Qinli Zhang

Scientific Tracks Abstracts: J Clinic Toxicol

Abstract :

I nvestigators have linked aluminum accumulation in the brain as a possible contributing factor to neurodegenerative disorders such as Alzheimer?s disease. The present study aimed at the mechanism underlying aluminum-induced neuronal cell death and identifies necrostatin-1, a specific inhibitor of necroptosis (programmed necrosis), as a substance which counteracts several of aluminum?s neurotoxic effects. When aluminum was injected into the cerebral ventricles of living mice, brain tissue analysis revealed shrunken and abnormal-looking neurons. When Nec-1 was injected simultaneously with aluminum into the ventricles, more surviving neurons could be seen, especially when higher doses of Nec-1 were used. Cell death-related proteins in the brain, a marker protein of necroptosis known as RIP1 showed the most changes, compared to marker proteins of apoptosis or autophagy. Similar findings were found for Alzheimer-related proteins: aluminum exposure increased the expression of mGluR2, mGluR5, Aβ, and Tau levels while Nec-1 treatment resulted in dose-dependent reductions of these protein levels. Progressive cell loss in specific neuronal populations associated with typical learning and memory dysfunction is a pathological hallmark of neurodegenerative disorders, especially in AD. The present study demonstrates that Nec-1, in addition to its use as a therapeutic agent for cell death, might therefore be of use in slowing the progression of the cognitive deficits associated with neuronal degeneration.

Biography :

Qinli Zhang has completed her Ph.D. and postdoctoral studies from Shanxi Medical University, China. She is now enrolled in Purdue University as a visitor scholar in Prof. Wei Zheng?s lab. She has published more than 40 papers in reputed journals and has been serving as an editorial board member of repute