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Rajendra Institute of Technology & Sciences, India
Posters-Accepted Abstracts: J Pharma Care Health Sys
Various extracellular signals regulates intracellular functions like neuron excitability, neurotransmitter biosynthesis and release, neuronal growth, differentiation, neurite growth, synaptic plasticity and cognition through secondary messengerâ�?�?s Cyclic AMP (cAMP). Secondary messengers subsequently activate target enzymes Protein Kinase A (PKA) & Protein Kinase G (PKG) that activate cyclic AMP Responsive Element Binding Protein (CREB) which regulate synaptic plasticity, learning and memory, restore energy levels, reduce excitotoxic damage prevent A�?² toxicity inhibit apoptotic and necrotic cell death and also increase synaptic strength. Forskolin activates the enzyme adenylyl cyclase and increases intracellular levels of cAMP. cAMP is an important second messenger necessary for the proper biological response of cells to hormones and other extracellular signals. It is required for cell communication in the hypothalamus/pituitary gland axis and for the feedback control of hormones. Cyclic AMP acts by activating cAMP-sensitive pathways such as protein kinase A. Various natural products, one of them being forskolin are an example of innovative drug research on natural products. Applied with rolipram, forskolin provides a route to inhibition of colon cancer cell growth and survival. These two drugs also work together to induce long-term potentiation in neuronal populations. To date, there have been more than two clinical studies examining the effectiveness of forskolin as a weight loss aid. Clinical studies with forskolin eye-drops in patients with open angle glaucoma were performed. Forskolin may be helpful in controlling the underlying cause of glaucoma. Increase skinâ�?�?s natural resistance to burning under UV light. Forskolin can also be used to promote nerve repair by increasing cAMP concentrations. Forskolin can activate or up-regulate the proliferation of Schwann cells in culture, together with fibroblast growth factor or transforming growth factor-beta. Various experimental studies are underway in using Forskolin as an adjuvant in treatment for diseases such as Parkinsons and/or nerve damage caused by trauma/accident. Based on important and versatile role of Forskolin, it is a matter of research to investigate the role of cAMP mediated CREB activation via Forskolin.