Journal of Thyroid Disorders & Therapy
Open Access
ISSN: 2167-7948
+44 1300 500008
ISSN: 2167-7948
+44 1300 500008
Daniel Igor Branovan
New York Ear, Nose and Throat Institute, USA
Posters & Accepted Abstracts: Thyroid Disorders Ther
Background: The results of international and local ultrasound screening programs aftermath the Chernobyl accident (1990-2005) had shown high variations of Thyroid cancer prevalence among children: 0.2%-0.6% in Gomel, 0.3% in Brest, and 0.008% in Mogilev Oblasts of Belarus. Aim: The aim of this study was to evaluate the pathological and clinical characteristics of radiation induced Papillary Thyroid C arcinoma (PTC) in childhood population. Patients & Methods: The pathological and clinical characteristics were investigated in 1078 children and adolescents with PTC who were surgically treated during the years 1990 through 2005. Ultrasonic particularities of Thyroid carcinoma in children exposed to radio-nuclides could be characterized as following: presentation into nodular ��? 95% and diffuse forms - 5%. The tumors mostly are visualized as a hypo-echogenic node - 56% with irregular margins -76%. Cervix lymph nodes were visualized in 42% cases. Results: According to the morphological data pediatric patients had high rates of metastatic PTC at presentation (73.8% - lymph nodes involvement, 11.1% distant spread). The overall survival was 96.9% with a median follow-up of 16.21 years, and 20-year eventfree survival and relapse-free survival were 87.8% and 92.3% respectively. Patients had significantly lower probability of both locoregional (P<0.001) and distant relapses (P<0.005) after total Thyroidectomy and radioactive iodine therapy. The prevalence of SPM in this unique cohort was 1%. Conclusion: Our investigation had shown that the incidence rates of pediatric Thyroid cancer in Belarus is related to levels of radiation exposure, Thyroid cancer screening, iodine deficiency and nitrates concentration in groundwater.
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