Awwad Abdoh Radwan Salama
King Saud University, Saudi Arabia
Scientific Tracks Abstracts: J Nanomedine Biotherapeutic Discov
The accumulation of amyloid beta peptide Aβ1-42 in the brain is a critical early event in the progression of Alzheimer's disease. Four floavonoid compounds isolated from Psoralea fruits (PF) were found to have anti-Alzheimer properties in vitro and in vivo in recent research. These natural compounds inhibited Aβ1-42 aggregation in a promising way. Docking studies and molecular dynamics (MD) simulations were used in our work to conduct a molecular modeling study on the substances as potential Aβ1-42 aggregation inhibitors. A molecular mechanics calculation was performed to determine the binding free energy, gain insight into the binding modes of the ligands, and pinpoint the key interacting residues.
Awwad Salama received his B.S. in pharmaceutical sciences from Assiut-Egypt, Assiut University 1988, where he named as administrator member and got his MD in Pharmaceutical Organic chemistry in 1995. He got his Ph.D. in computer-aided drug discovery from Tokyo-Japan, Kitasato University in 2002. 2002-util now, he named as lecture, associate professor and professor at Faculty of Pharmacy, Assiut University, Egypt. In 2008-untill now, he moved to College of Pharmacy, King Saud University, KSA. Awwad’s work has led to 65 publications, 2 patents and several conferences’ participations. He got two awards From ‘ACDIMA Award as a co-author for best research from ACDIMA drug company (Oman, Jordanian’ years 2008 and 2012) and he got Silver Medal from Geneva Innovation Salon (Swizerland, 2-6 April 2014).