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Minimization and optimization of water use in the process of clea | 2486
Journal of Developing Drugs

Journal of Developing Drugs
Open Access

ISSN: 2329-6631

Minimization and optimization of water use in the process of cleaning containers


3rd International Summit on GMP, GCP & Quality Control

September 25-26, 2014 Valencia Convention Centre, Spain

Hanane El Asslani

Accepted Abstracts: J Dev Drugs

Abstract :

This study concerns the minimization and optimization of water use in the process of cleaning containers in pharmaceutical industry. This process of cleaning is composed by four steps: prewashing, washing with an alkaline detergent, rinsing with city water, and final rinsing with purified water. Each step is considered as a factor, and the process of cleaning is studied by using a Design of Experiments (DOE). DOE allowed us to select points so that we maximize the accuracy of the information that we get from the experiments. A Central Composite Design was used to plan and to interpret controlled tests. In this study, we have two responses which are the residual concentrations of Active Pharmaceutical Ingredient and of detergent obtained after cleaning containers. These residual concentrations are obtained after swab sampling and by using ionic chromatography and UV spectrophotometry methods. The aim of this study is to determine the steps of the cleaning process that have no effect on the responses, and in which we could minimize the amount of water used. The construction of a response surface could be used to optimize and to minimize the water use while keeping residual concentrations of API and detergent in respect with the criteria acceptance.

Biography :

Hanane El Asslani earned a Biochemistry Engineer Degree from National Institute of Applied Sciences (INSA de Toulouse). Working at Merial, a world-leading animal health company, in the production support department, he is in charge of the cleaning process validation related to the production of solutions for injection and dry pharmaceutical forms.

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