Organic Chemistry: Current Research
Open Access

Microwave assisted synthesis of a library of near-infrared molecular probes for in-vivo imaging

24^th Global Organic & Inorganic Chemistry Conference

July 18-19, 2018 | Atlanta, USA

Maged Henary

Georgia State University, USA

Keynote: Organic Chem Curr Res

Abstract :

A microwave-assisted method for the synthesis of a library of Near-Infrared (NIR) molecular probes such as symmetrical pentamethine cyanines and their corresponding precursors. This class of compounds is advantageous for in vivo imaging because of the low absorption of biological molecules in the NIR window. The microwave synthesis drastically reduced the reaction time for dye synthesis from days to min, as well as producing increased yields (89-98%) to the conventional heating method (18-64%). Also in this study, we demonstrate that it is possible to create tissue-specific (thyroid, salivary, and adrenal glands) near-infrared fluorophores using the inherent chemical structure. Thus, a single compact molecule performs both targeting and imaging.

Biography :

In 1990, Maged Henary received his BSc. degree in chemistry from Alexandria University and in 2000 he received his Ph.D. degree in organic chemistry from Georgia State University (GSU) under the supervision of Professor Strekowski. Afterward, he joined Professor Fahrni’s lab at Georgia Institute of Technology. Dr Henary developed sensors for imaging microscopy of labile zinc and copper pools in live cells. In 2005, he was appointed Lecturer at GSU instructing Undergraduate classes. In 2011, he accepted a position as Assistant Professor at GSU. His research focuses on the development of heterocyclic compounds, including NIR dyes for bioanalytical applications.

E-mail: mhenary1@gsu.edu