Endocrinology & Metabolic Syndrome
Open Access
ISSN: 2161-1017
ISSN: 2161-1017
Dr. George Eskandar
North Wales Hospitals, United Kingdom
Scientific Tracks Abstracts: Endocrinol Metab Syndr
Introduction: Globally, colorectal cancer (CRC) is one of the most typical lethal cancers. One of the main factors for better outcomes in CRC management is the early detection of the disease. As an integral component of human metabolism and homeostasis, gut microbiome has recently been a subject of extensive research for its role in the pathogenesis, diagnosis, and treatment of CRC. Microbial dysbiosis (the decrease in beneficial gut flora and the increase of detrimental populations) leads to chronic inflammation and genetic alteration in the host cells, triggering and promoting CRC carcinogenesis. Identifying these microbial changes in depth would potentially isolate the pathogenic microbiota species and establish biomarker models for early detection of CRC. On the other hand, modifying these microbial changes would help formulate preventative and therapeutic strategies for CRC, developing a more precise CRC management plan according to each patient’s microbial print. This essay explains gut microbiome composition, microbial changes (dysbiosis) in CRC carcinogenesis, the probability of creating microbiomebased CRC biomarkers, and potential microbiome-targeted treatment option Conclusions A substantial body of research has established a strong relationship between microbial alterations (dysbiosis) and CRC carcinogenesis. However, the precise microbial-host interactions in CRC development remain elusive and influenced by various cofactors (exogenous and endogenous). Some studies have expressed that microbiome alterations can be modified to treat CRC. However, more sophisticated molecular-based analysis and prospective interventional studies may yield more specific CRC microbial biomarkers and personalized therapeutic techniques for CRC management.
George is a vascular surgery registrar, mainly works in vascular and general surgery. He is interested in aorta and carotid research. He has at least 6 published papers. Through his work he hopes that his research activity would be valuable to help people all over the world. George Eskandar is working as a general and vascular Surgeon in James Cook University Hospital, England in UK.