Micelles catalyzed chemo and regio-selective synthesis of substit | 33734
Organic Chemistry: Current Research

Organic Chemistry: Current Research
Open Access

ISSN: 2161-0401

+44 1478 350008

Micelles catalyzed chemo and regio-selective synthesis of substituted quinones in H2O as potent antimicrobial and anticancer agents

3rd International Conference on Past and Present Research Systems of Green Chemistry

September 19-21, 2016 Las Vegas, USA

Vishnu Kumar Tandon

University of Lucknow, India

Posters & Accepted Abstracts: Organic Chem Curr Res

Abstract :

The extensive use of water as a medium for organic synthesis has been due to concept and language of Sharpless et al., where reactions were carried out in aqueous solutions for cases where reactants are insoluble in water. The surfactant-type catalysts play a dual role both as a catalyst to activate the substrate molecules and as a surfactant to increase the concentration of organic reactants to form micelle particles in water. In connection with our studies on the reactivity of 1,4-benzo and naphthoquinones with carbon, nitrogen and sulfur nucleophiles in aqueous medium and the utility of surfactants in aqueous medium, we have carried out reactions of 1,4-benzo and naphthoquinones and its derivatives with carbon, nitrogen and sulfur nucleophiles by economical green methodology approach using surfactant as a catalyst. The green methodology approach employing micelles as green catalysts has led to synthesis of 1,4- benzo and naphthoquinones derivatives which have been evaluated for their antimicrobial and anticancer activity. The detailed synthesis and biological activity of potent drug candidates will be discussed.

Biography :