Metalloproteinase 9 levels of the extracellular matrix and ambula | 53506
Clinical & Experimental Cardiology

Clinical & Experimental Cardiology
Open Access

ISSN: 2155-9880

+44 1300 500008

Metalloproteinase 9 levels of the extracellular matrix and ambulatory blood pressure monitoring in individuals with pre-hypertension

8th Global Cardiologists & Echocardiography Annual Meeting

July 18-20, 2016 Berlin, Germany

Flavia Mariana Valente

S�?£o Jos�?© do Rio Preto, Brazil

Posters & Accepted Abstracts: J Clin Exp Cardiolog

Abstract :

The term pre-hypertension is employed when systolic blood pressure ranges from 120 to 139 mmHg or diastolic blood pressure ranges from 80 to 89 mmHg. This new classification was introduced due to the excessive mortality and high conversion rates to clinical hypertension among individuals with a marginal increase in blood pressure. Besides being associated with an increase in the incidence of cardiovascular events, prehypertension is an intermediate pathway to full hypertension, which makes adequate diagnosis and treatment essential. Ambulatory blood pressure monitoring is a good tool for the evaluation overall of cardiovascular risk and important to the diagnosis and prognosis of hypertension. This measure can contribute to the stratification of individuals with prehypertension based on variables such as central blood pressure and arterial stiffness with the aim of defining individuals with prehypertension that could benefit from treatment. Moreover, aspects involved in vascular remodeling and arterial stiffness are highlighted among the different physiopathological mechanisms that characterize the multifactor etiology of high blood pressure. Recently, there has been increasing interest in the study of proteolytic enzymes, such as metalloproteinases (MMPs), which are found at elevated levels in patients with poor cardiovascular outcomes. The increased activity of MMPs can impair vascular relaxation and consequently contribute to hypertrophy of the arterial walls, leading to vascular dysfunction and contributing to an increase in arterial stiffness. Despite reports of this association, few studies in the literature have addressed MMP levels and their association with arterial stiffness in populations with different degrees of arterial hypertension, especially those with prehypertension.

Biography :