Organic Chemistry: Current Research
Open Access

Metal containing nucleosides that function as therapeutic and diagnostic agents against brain cancer

2^nd International Conference on Past and Present Research Systems of Green Chemistry

September 14-16, 2015 Orlando, USA

Jennifer N Williams

Cleveland State University, USA

Posters-Accepted Abstracts: Organic Chem Curr Res

Abstract :

Personalized medicine incorporates the concept of tailor-made drugs and medications applied to individual patients to efficiently treat many illnesses. By applying the concept of â�?�?theranosticsâ�?, fluorescent biophores that serve dually as therapeutic and diagnostic agents,can be used for biological imaging, testing and treatment, while eliminating the use of more dangerous, radioactive, and unstable materials.Nucleoside transporters play important roles in the increased nucleoside metabolism necessary for the higher levels of DNA and RNA synthesis associated with hyperproliferative capabilities of cancer cells. In this study a series of metal containing nucleoside (MCN) analogues have been used as novel chemical agents to study how nucleosides are imported into cells. The transport and toxicity of cyclometalated iridium nucleosides, designated Ir(III)-PPY, Ir(III)-BZQ, and Ir(III)-PBO, have been evaluated against a glioblastoma brain cancer cell line, U-87. Cell viability experiments demonstrate that all compounds induce cell death in a time- and dose-dependent manner. Significant nuclear localization is detected at longer times (~24 hours), corresponding with the onset of cell death and provides insight into the mechanism of action of these MCNs. The collective photophysical properties of these fluorescent MCNs were also used to visualize their intracellular distribution throughout localized regions of the cell. The ability to measure the uptake of MCNs coupled with their anti-cancer activities define these novel nucleoside analogues as â�?�?theranostic agents.â�? Further development of cyclometalatediridium chemotherapeutics from non-natural nucleosides as mechanistic probes against cancer propose safer and more effective methods of diagnosis and treatment for many illnesses associated with hyperproliferative cells.

Biography :

Email: AmbitiousChemist@Gmail.com