Drug Designing: Open Access
Open Access
ISSN: 2169-0138
ISSN: 2169-0138
Julie Fernanda Benavides Arevalo
CES University, Colombia
Posters & Accepted Abstracts: Drug Des
The mineral deficiency in the human population has been associated with metabolic, hormonal and immunological disorders. Oligoelements such as copper, magnesium, manganese and zinc are involved in several metabolic, enzymatic and immunological processes. They are also important for the integral tissue proteins and could be involved in gene expression regulation. The deficiency of these essential elements hampers the appropriate function of the body and may cause various diseases. Therefore, it is important to guarantee the incorporation of these trace elements in the diet, but the quantity provided is not always adequate for the optimum body performance. Currently, conventional nutritional supplements have two major problems. The first one is attributed to the association of inorganic salts with metals which might cause low absorption and gastric intolerance. The second problem is caused when several metals are present in a formulation which could lead to possible antagonistic interactions. For this reason, I explore the development metal complexes with amino acids (i.e., glycine and asparagine) could be an alternative and better way for metals intake in the human body. Therefore, the amino acids metabolic pathways can be useful for the rapid and effective absorption of metals. In this way, the cumbersome gastric side effects of commercial nutritional supplements could be avoided. The in vitro dissolution studies provides an important tool for the development of oral dosage forms and gives an indication of lot-to-lot variability and predicts the bioavailability of these products. The synthesis and verification of the formation of complexes were carried. The compatibility of the complex with excipients was determined. The solubility, dissociation constant, dissolution efficiency, dissolution rate, the effect particle size, reactive fractal dimension, morphology and particle surface characteristics of these complexes were also assessed.