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Reproductive Medicine Associates of New York, USA
Posters-Accepted Abstracts: Endocrinol Metab Syndr
Metabolomics offers the promise of a new non-invasive tool for identifying the underlying causes of poorer embryo development from women with PCOS. The association between poorer reproductive outcomes and the diagnosis of PCOS has been established for decades. However the underlying mechanism leading to poorer embryo development in this patient type remains unknown. Metabolomics is the study of metabolites consumed from or secreted into the embryo culture media, in which the embryo has been developing. Highly sensitive ultra-high performance liquid chromatography coupled to mass spectrometry (UPLC-MS) methods allows the identification of metabolites present in volumes of 50 micro liters. Recent studies have discovered differences in the concentration of saturated fatty acids in the spent culture media of embryos from women with PCOS compared to embryos from non-PCOS women. Fatty acids are widely accepted as potential metabolic substrates for of oocytes and embryos and an alteration in their abundance has been shown to lower competency of bovine oocytes and embryos. By elucidating the underlying mechanisms behind the lower implantation potential of embryos from women with PCOS, current treatments may be modified to improve outcomes and new treatments can be developed specifically for women with the diagnosis of PCOS.
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