Drug Designing: Open Access
Open Access
ISSN: 2169-0138
ISSN: 2169-0138
Mahaveer Singh and Hemant R Jadhav
Birla Institute of Technology and Sciences-Pilani, India
Posters & Accepted Abstracts: Drug Des
Melatonin is a chronobiotic substance which acts as synchronizer by stabilizing bodily rhythms. Its synthesis occurs in various locations in the body, including the pineal gland, skin, lymphocytes and gastrointestinal tract (GIT). Its synthesis and secretion is controlled by light and dark conditions, whereby light decreases and darkness increases the production. Melatonin is also known as the ��?hormone of darkness��?. Melatonin and analogs that bind to the melatonin receptors are important because of their role in the management of depression, insomnia, epilepsy, Alzheimer��?s disease (AD), diabetes, obesity, alopecia, migraine, cancer, and immune and cardiac disorders. Histamine H3 receptors are found mostly in central nervous system, and are involved in regulation of release of various neurotransmitters in brain. They have been implicated with diverse potential therapeutic applications including sleep-wake disorders, attention-deficient hyperactivity disorder, epilepsy, cognitive impairment and obesity. Here is need of designing dual ligands which have both the properties as melatonin receptor stimulation and Histamine 3 receptor antagonism. These kind of ligands will be very much useful in the treatment of various CNS disorders specially epilepsy.
Email: mahaveer2singh@gmail.com