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Mechanism of mesenchymal stem cells-involved vascular repair/ remodeling
Journal of Cell Science & Therapy

Journal of Cell Science & Therapy
Open Access

ISSN: 2157-7013

Mechanism of mesenchymal stem cells-involved vascular repair/ remodeling


3rd World Congress on Cell Science & Stem Cell Research

November 20-22, 2013 DoubleTree by Hilton Baltimore-BWI Airport, MD, USA

Mei Wan, Changjun Li and Gehua Zhen

Johns Hopkins University School of Medicine, USA

Accepted Abstracts: J Cell Sci Ther

Abstract :

Transforming growth factor (TGF) ?² is maintained in a sequestered state in extracellular matrix as a latent form, which is considered as a molecular sensor that releases active TGF?² in response to the perturbations of the extracellular matrix. The biological implication of the temporal discontinuity of TGF?² storage in the matrix and its activation is obscure. We show that active TGF?² controls the mobilization and recruitment of (messenchymal stem cells) MSCs to participate in tissue repair and remodeling. MSCs were mobilized into the peripheral blood in response to vascular injury and recruited to the injured sites where they gave rise to both endothelial cells for reendothelialization and myofibroblastic cells to form thick neointima. Intravenously injection of recombinant active TGF?²1 in uninjured mice rapidly mobilized MSCs into circulation. Further, inhibitor of TGF?² type I receptor blocked the mobilization and recruitment of MSCs to the injured arteries. Thus, TGF?² is an injury-activated messenger essential for the mobilization and recruitment of MSCs to participate in tissue repair/remodeling.

Biography :

Mei Wan, M.D., Ph.D. is an Associate Professor of the Center for Musculoskeletal Research, Department of Orthopaedic Surgery at Johns Hopkins University School of Medicine. She got her M.D. at Hebei Medical University in 1991. She obtained her Ph.D. in Pathophysiology at the same school in 1997. In 1998, she came to University of Alabama at Birmingham (UAB) as a postdoctoral fellow. In a series of highly cited papers, she demonstrated that the importance of this proteosome degradation pathway and control of TGFβ signaling. She got the Young Investigator Award at the American Society for Bone and Mineral Research Annual Meeting in 2000. She then took an Assistant Professor position in 2004 at UAB where she identified the central mechanism through which parathyroid hormone stimulates bone formation, which had been the major unresolved question in the bone field. She took an Associate Professor position at Johns Hopkins University in 2009. Her research focuses on understanding how TGFβ/ Smads signaling regulates the behavior of mesenchymal stem cells (MSCs) in tissue homeostasis, repair and remodeling. In particular, she found that active TGFβ can be released from tissue in response to perturbations to the local environment such as bone remodeling (Nat. Med. 2009, Cell Stem Cell 2011) and arterial injury (Stem Cells 2012). The released active TGFβ stimulates the migration of MSCs to participate in tissue repair or remodeling. Currently, she is an editorial board member for Journal of Bone and Mineral Research and Bone Research.

Email: [email protected]

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