Journal of Clinical Toxicology
Open Access

Lambda-cyhalothrin-induced reproductive toxicity and histopathological alterations in male mice

4^th Global Summit on Toxicology

August 24-26, 2015 Philadelphia, USA

Ali S Al-Sarar, Yasser Abobakr, Alaa E Bayoumi, Hamdy I Hussein and Mousa Al-Ghothaimi

Posters-Accepted Abstracts: J Clin Toxicol

Abstract :

Lambda-cyhalothrin is a broad-spectrum pyrethroid insecticide. The reproductive toxicity and histopathological effects of lambdacyhalothrin
was studied in male mice. Oral administration of lambda-cyhalothrin to adult male mice at 3 doses (0.2, 0.4, and 0.8
mg/kg body weight) for 6 weeks caused a significant reduction in the weight of the seminal vesicles and an increase in the count of
morphologically abnormal spermatozoa. The highest dose caused a significant reduction in the epididymal sperm count compared
with the control. The medium and the high doses decreased the percentages of live and motile spermatozoa compared with control
mice. Histopathological examination of the testes, liver, spleen, and kidneys showed dose-related degenerative damage in lambdacyhalothrin-
treated mice. The results indicate that lambda-cyhalothrin has reproductive toxicity, hepatotoxicity, splenotoxicity, and
nephrotoxicity in male mice at the tested doses.

Biography :

Ali S Al-Sarar has completed his PhD from Ohio State University and Postdoctoral studies from Stanford University School of Medicine. He is an Associate Professor at King
Saud University. He has published more than 25 papers in reputed journals.