Journal of Proteomics & Bioinformatics
Open Access

IPE-Industrial protein engineering: Accelerated evolution

International Conference on Protein Engineering

October 26-28, 2015 Chicago, USA

Frits Goedegebuur

DuPont Industrial Biosciences, The Netherlands

Scientific Tracks Abstracts: J Proteomics Bioinform

Abstract :

Historically, the protein design process has been approached as equivalent to the problem of finding in all of protein space the one best sequence for a single property. For accelerated evolution, the problem to be solved is to identify at least one protein sequence that meets or exceeds the minimum value required for a number of properties. Protein engineered proteins came about through accumulation of point mutations that were not deleterious for any important property. Using the â�?�?Super-screenâ�? process, we can determine all those mutations in a matter of weeks for any protein for all important properties. Combining these mutations in the proper way can rapidly produce a protein with all desired properties.

Biography :

Frits Goedegebuur is currently working for DuPont Industrial Biosciences (2011) as a Senior Scientist. He is a Member of DuPont’s R&D management team and he is a Project Leader of a global protein engineering research project. He has filed ~120 patents, of which ~60 patents have been granted.

Email: Frits.Goedegebuur@dupont.com