Journal of Proteomics & Bioinformatics
Open Access

Ionotropic glutamate receptors revealed higher selectivity to ß-ODAP compared to its native agonist-glutamate

2^nd International Conference on Proteomics & Bioinformatics

July 2-4, 2012 Embassy Suites Las Vegas, USA

Amol L. Shirfule, Arjun L. Khandare and Raju Naik Vankudavath

Scientific Tracks Abstracts: J Proteomics Bioinform

Abstract :

Ionotropic Glutamate Receptors (iGluR) are important in development and functions of nervous system and are implicated in the etiology of various dysfunctions like Alzheimer?s, Parkinson?s and Neurolathyrism. This receptor mediate excitatatory synaptic transmission through ligand induced opening of transmembrane ion channels. In this study we employed the molecular modeling approach to explore the binding affinities of glutamate and β-ODAP (β-N-oxalyl-L,α,β-diamino propionic acid) with the (iGluRs) by using Accelrys Drug Discovery suite. The molecular modeling studies revealed promising binding interactions of these ligands with the iGluRs amino terminal domain (PDB ID: 3SAJ). The ligand ? target model generated by Discovery studio is validated by Ramachandran plot in PROCHECK analysis. The results obtained suggests a novel mechanism by which the amino terminal domain of iGluRs participating in these interactions.

Biography :

Amol L. Shirfule has completed his Ph.D at the age of 29 years from S.R.T.M.University and postdoctoral studies at Food & Drug Toxicology Research Centre, National Institute of Nutrition, I.C.M.R., Govt. of India. He has published more than 6 papers in reputed journals and serving as a Post Doctoral Associate at National Institute of Nutrition.