Internal Medicine: Open Access
Open Access

Influence of pegylated interferon and Ribavirin on insulin resistance and metabolic factors in patients with chronic hepatitis C

International Conference on Internal Medicine

October 31-November 02, 2016 San Francisco, USA

Zeynep Altin, Serhat Ozer, Betul Koyuncu, Elcin Erdogan Yucel, Fatih Aslan and Belkis Unsal

Tepecik Education and Research Hospital, Turkey
Haydarpasa Numune Training and Research Hospital, Turkey
Katip Celebi University Ataturk Training and Research Hospital, Turkey

Posters & Accepted Abstracts: Intern Med

Abstract :

Aims: This study was aimed to evaluate the effect of pegylated interferon alfa 2a/2b and ribavirin, the agents used in chronic hepatitis C on insulin resistance and metabolic factors. Methods: A total of 104 chronic hepatitis C patients applying to Katip Celebi University Ataturk Research and Training Hospital, Department of Gastroenterology between 01.01.2005-01.11.2012 with ages ranging from 20 to 75 years having serum insulin (0 and 48 weeks) and HCV-RNA (0, 12, 24, 48 and 72 weeks) levels available were included in the study. These parameters were assessed according to the groups based on response to therapy (sustained virologic response SVR, relapse and non-responders). Results: Of the 104 patients, SVR was achieved in 55 but 49 (non-SVR). In univariate analyses, no statistically significant association was obtained in gender, age, body mass index, waist circumference, total cholesterol, triglyceride, LDL-cholesterol, HDL-cholesterol, fasting plasma glucose plus insulin and HOMA score at week 0, platelet, arterial blood pressure, degree of steatosis and the last but not least histological activity index between SVR and non-SVR groups. However, a statistically significant difference was noted in GGT, insulin level plus HOMA score and existence of insulin resistance at week 48, log HCV-RNA and fibrosis between the aforementioned groups (p<0,05). In multivariate analysis, it was concluded that log HCV-RNA, triglyceride and week 48 insulin resistance had influence on SVR (p<0.05) while age, body mass index and fibrosis did not. Conclusions: Insulin resistance is accepted to have a negative effect of SVR. Insulin resistance may improve once SVR is achieved. In this context, it can be advocated that the regression of insulin resistance at week 48 detected in 0 week may be a predictive factor for SVR at week 72.

Biography :

Email: zeynpdr@hotmail.com