Endocrinology & Metabolic Syndrome
Open Access

Importance Of Catecholamines Metabolites (Metanephrines) levels in patients with Pheochromocytomas in relation to tumor size

19th World Congress on Endocrinology & Diabetes

November 22-23, 2023 | Webinar

Mina Aziz

Aneurin Bevan University Health Board, United Kingdom

Scientific Tracks Abstracts: Endocrinol Metab Syndr

Abstract :

Introduction: Pheochromocytomas are rare neuroendocrine catecholamine-producing tumors that arise from either the adrenal medulla (PHEO) or extra-adrenal paraganglionic tissues (paraganglioma/PGLs). PHEO is responsible for about 0.01- 0.1% of the cases of hypertension. Assessment of the plasma/urinary levels of metanephrines (catecholamines metabolites) is now considered the gold standard for the diagnosis of PHEOs. In this study, we aimed to investigate the role of the plasma and 24-hour urinary metanephrines levels in the diagnosis of PHEO/PGLs. Patients and Methods: Retrospective review of 25 patients diagnosed with PHEO/PGLs. We measured the plasma and 24-h urinary levels of metanephrines and normetanephrines. The data were compared with another set of 25 patients with other adrenal pathologies. The correlation coefficient between the tumor sizes and the plasma/24-hour urinary metanephrines levels was calculated. Resuls: The mean tumor size was 4.63cm. The sensitivity and specificity rates for plasma metanephrines were (80-92%) and (92-96%), respectively, while for 24-hour urinary metanephrines were (80-90%) and (95-100%), respectively. We found a strong positive relationship between the tumor size and the plasma levels of normetanephrine (r = 0.518, P �? 0.01), and metanephrine (r = 0.577, P �? 0.01). While the relation with the 24h urinary concentrations of normetanephrine (r = 0. 384, P = 0.01) and 24-hour urinary metanephrine (r = 0.138, P �? 0. 01). Conclusion: Plasma/24-hour urinary metanephrines are of great value in the diagnosis PHEOs/ PGLs as they are continuously produced by the tumor. There are strong relations between the size of these tumors and the plasma and urinary concentration of these metabolites, which can help to predict the size of the tumor even before imaging.

Biography :

Mina Aziz is working as a researcher at Aneurin Bevan University Health Board in united kingdom. He is also a trust member in the South Tees Hospital, NHS Foundation trust. He has published many articles in the reputed journals.