National Institute of Pharmaceutical Education and Research, India
Posters & Accepted Abstracts: J Pharma Care Health Sys
Oral route is considered as the most natural, convenient and safest route of drug administration involving higher patient compliance, lesser complications and cost-effectiveness as compared to parental drug delivery. Nevertheless, therapeutic efficacy of a large number of perorally administered drugs is often obscured by their poor oral bio-availability (BA) attributed to their extensive first pass metabolic effect by cytochrome P-450 liver microsomal enzyme system as also their efflux by an over expressed plasma membrane transporter P-glycoprotein efflux pump (P-gp). In recent years, the exploitation of nanotechnology for oral application has experienced phenomenal strides. Among the broad spectrum of nanocarriers that has shown promise in oral drug delivery, polymeric and lipidic nanoparticles (NPs) deserve special mention. These nanoparticles, when administered via oral route, are taken up by the M cells in PayerÃ¢Â?Â?s patches and transported from the gut lumen to intraepithelial lymphoid cells and thereafter into the blood stream through the lymphatic system. This special transport pathway plays a distinct role in enhancing the BA of NP encapsulated drug while avoiding enzymatic degradation in enterocytes, first pass metabolism in liver and concomitant reduction in dose and drug associated toxicity. The present talk will focus on the various nanocarriers viz. polymeric nanoparticles, lipidic nanoparticles, liposomes, SEDDS, drug nanocrystals etc. developed by our group for bioavailability enhancement of wide range of bioactives.