Implant of autologous adult’s bone marrow stem cells | 41370
Journal of Cell Science & Therapy

Journal of Cell Science & Therapy
Open Access

ISSN: 2157-7013

+44 1300 500008

Implant of autologous adult’s bone marrow stem cells in heart failure: Functional class IV

10th World Congress and Expo on Cell & Stem Cell Research

March 19-21, 2018 | New York, USA

Matias Fernandez Vina

Interamerican Open University, Argentina

Posters & Accepted Abstracts: J Cell Sci Ther

Abstract :

Objectives: The objectives of this studies are to demonstrate that CD34+/CD38- adult stem cells in myocardial tissue generate a significant increase in the ejection fraction after implantation and to observe the improvement in the quality of life of the implanted patients, evaluating the reduction of dyspnea and the number of hospitalizations. Material & Methods: A descriptive, observational study of 71 and 88-year-old patients with a history of CF IV heart failure with severe deteriorated FEY (<30%) who suffered hospitalizations every 15 days, due to biventricular dysfunction. They were submitted to implantation of bone marrow stem cells through retrograde venous technique in coronary sinus with balloon occlusion by femoral catheterization. A pre/post implant echocardiogram was indicated for comparisons (7 months) and a post-implant effort ergometry test was performed. Results: After a period of 210 days, a significant improvement in the ejection fraction of approximately 8% and 14% was observed with respect to the baseline (P:0.05) and a decrease in both hearts mass of 20% (grams). In addition, it was observed that the patients did not have recurrence in hospital admissions successively every 15-20 days, cause congestive heart failure and that there is a remarkable improvement in the quality of life rapidly after the implantation of stem cells. The post-implant ergometry test, at 210 days, turned out to be encouraging, since the patient tolerated the stress test greater than six minutes. Conclusion: The implantation of stem cells generated a favorable decrease in the number of hospital readmissions of the evaluated patients and showed improvement of their quality of life after no dyspnea CF IV. It was corroborated that there is a significant improvement of the ejection fraction, with decrease of the mass of the implanted organ.