Organic Chemistry: Current Research
Open Access
ISSN: 2161-0401
ISSN: 2161-0401
Abdelhadi Fatima Zohra
University Oran 1 Ahmed Ben Bella, Algeria
Posters & Accepted Abstracts: Organic Chem Curr Res
The Huisgen’s terminally induced 1,3-dipolar cycloaddition is one of the most popular reactions that has been adapted to produce the substituted 1,2,3-triazole. This heterocyclic compound plays an important role in several domains and is an important class due to their biological activity, such as: agents anti-inflammatory, anti-microbial, Anti-bacterial, anti-tubercular, anti-cancer, anti-viral, anti-oxidant, anti-malarial, antihistaminic, antiproliferative, and anti-HIV. The synthesis of 1,2,3-triazole derivatives is developed in the presence of mesoporous catalysts such as MCM-41 and FSM-16, which have the advantage of being non-toxic, non-corrosive and causing no environmental pollution and easily separated from the reaction medium. A complete study was carried out to develop the reaction conditions of the dipolar-1.3 cycloaddition between azide aryls and alkynes. The synthesized molecules were evaluated for their in vitro antimicrobial potential against bacterial strains staphylococcus aureus and Escherichia coli, and two fungal strains candida albicana and Aspergillus niger.