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Violetta Csakvary, Tamas Puskas, Gyorgy Oroszlan, Peter Lakatos, Bernadett Kalman, Gabor L Kovacs and Erzsebet Toldy
Posters: Endocrinol Metab Synd
Aim: The study aimed to reveal important determinants of bone mass in Tanner stage I. Methods: We studied 84 healthy children (43 girls) aged 7 to 11 years. Serum estradiol (E2), 25-hydroxyvitamin D3-vitamin [25(OH)D3], intact parathyroid hormone (PTHi), osteocalcin (OC) and β-crosslaps (CTXs) were analyzed (Roche Diagnostics System). Total and spine bone mineral content (tBMC and LBMC) and density (tBMD and LBMD) were assessed, and total fat body mass index (FBMi) was calculated (DXA Lunar Prodigy). Results: Significant negative correlation was found between PTHi and 25(OH)D3 levels (p=0.011) in subjects and between E2 and 25(OH)D3 levels (p<0.05) in girls with elevated PTHi and with suboptimal 25(OH)D3 levels. Significant positive correlation (p=0.042) was detected between FBMi and E2 and between E2 and CTXs and OC (p<0.01 and p<0.03) concentration in girls. There was a significant correlation between E2 and all BMC and LBMD values in both genders. E2 was the only factor correlating with all dependent variables (BMCs, BMDs) in both genders. Conclusions: E2 levels play a key role in bone metabolism in both genders in prepuberty. The negative correlation between 25(OH)D and E2 and the positive correlation between PTHi and OC suggest that estrogens regulate PTHi indirectly and cause lower circulating 25(OH)D3 levels. We propose that the decreased levels of 25(OH)D3 reflect not the real vitamin supply, but may rather be the result of E2 regulation. Therefore, the actual serum 25OHD levels may underestimate the availability of factors supporting bone formation.
Violetta Cs�kv�ry is a Paediatrician, Neonatologist, Endocrinologist from Hungary. She has completed her PhD in the field of investigation of bone metabolism in healthy 6-18 years old children and Postdoctoral studies from Medical Universityl of P�cs. She has had 57 presentations of endocrinology and has published 9 papers in reputed journals.