Glyphosate and its most popular product (Roundup) affect the secr | 55638
Journal of Clinical Toxicology

Journal of Clinical Toxicology
Open Access

ISSN: 2161-0495

+44 7868 792050

Glyphosate and its most popular product (Roundup) affect the secretion of myometrial contractions regulators from bovine ovary and uterus in vitro

9th Euro-Global Summit on Toxicology and Applied Pharmacology

June 22-24, 2017 Paris, France

Michal H Wrobel

Institute of Animal Reproduction and Food Research, Polish Academy of Sciences, Poland

Scientific Tracks Abstracts: J Clin Toxicol

Abstract :

Glyphosate based herbicides are intensively used in modern agriculture. Therefore, the aim of the study was to investigate the effect of the pure glyphosate and its most popular product (Roundup) on hormonal regulation of the force of myometrial contractions. The myometrial, endometrial, granulosa and luteal cells, as well as the strips of myometrium, from non-pregnant cows, were incubated with the herbicides at doses (0.1, 1 or 10 ng/ml) which were closed to their environmental amount. Neither glyphosate nor Roundup affected the viability of studied cells. Glyphosate stimulated the secretion of testosterone (T) and estradiol from granulosa cells, while Roundup inhibited the T secretion. Both compounds decreased the secretion of progesterone while increased oxytocin (OT) secretion from luteal cells. Roundup significantly decreased prostaglandins (PGF2 and PGE2) secretion from endometrial but not myometrial cells. However, neither basal nor OT-stimulated myometrial contractions were affected by both compounds. The data show that the herbicides impaired the secretory function of ovarian and endometrial cells. Admittedly both compounds change the amount of regulators of uterine contractions, but they do not affect the force of myometrial contractions directly. The data clearly show that these herbicides can support the luteolytic process but may only indicate the potential of these compounds to disturb the regulation of smooth muscle motility.
The work is supported by National Science Centre (Project N N311 082140), Polish Academy of Sciences (GW29) and by the grant of KNOW Consortium "Healthy Animal â?? Safe Food", MS&HE Decision No. 05-1/KNOW2/2015

Biography :

Micha?? H Wróbel is currently an Associate Professor at the Institute of Animal Reproduction and Food Research of the Polish Academy of Sciences in Olsztyn (Poland). He earned his PhD in Faculty of Biology from the University of Warmia and Masury in Olsztyn, in 2008. In his thesis work he pioneered the adverse effect of chlorinated xenobiotics (polichlorinated biphenyls and pesticides) on bovine myometrial contractions. After completing his MSc, he worked as an Assistant Professor in the Department of Cattle Physiology and Endocrinology of the Institute of Animal Reproduction and Food Research, PAS. In 2009, he became an Associate Professor in the Department of Physiology and Toxicology of Reproduction of the Institute of Animal Reproduction and Food Research, PAS.