Journal of Clinical Toxicology
Open Access
ISSN: 2161-0495
+44 1478 350008
ISSN: 2161-0495
+44 1478 350008
Awais Ihsan
COMSATS Institute of Information Technology, Pakistan
Posters & Accepted Abstracts: J Clinic Toxicol
Quinocetone is a novel quinoxaline hetrocyclic-N-dioxide compound which is widely used in China to improve the growth and feed efficiency in food producing animals. It was evaluated for mutagenic potential in six Salmonella typhimurium strains (TA97, TA98, TA100, TA102, TA1537 and TA 1538). Five different concentration ranges from 1.0 �?¼g/ plate to 50 �?¼g/ plate were tested in the presence or absence of rat liver homogenate fraction S-9, along with positive and negative controls. Quinocetone was not found mutagenic in Salmonella typhimurium TA 102 strain, both in the presence and in the absence of S-9 fraction. QCT produced histadine dependent mutants at 6.9 �?¼g/plate in Salmonella typhimurium TA 97 (with or without rat liver S-9 fraction), Salmonella typhimurium TA 1537 (with rat liver S-9 fraction). At the dose of 18.2 �?¼g/plate, histadine dependent mutants were produced in Salmonella typhimurium TA 100 (with or without rat liver S-9 fraction), in TA 1535 (with rat liver S-9 fraction) and TA 1537 (without rat liver S-9 fraction). At the dose rate of 50�?¼g/plate, histadine dependent mutants were produced only in Salmonella typhimurium TA 98 (with or without rat liver S-9 fraction). These results highlighted the genotoxic potential of quinocetone in Salmonella typhimurium reverse mutation assay. It also extended knowledge about food safety and security issues of quinocetone.
Email: awais.dr@gmail.com