Current Synthetic and Systems Biology
Open Access
ISSN: 2332-0737
+44-20-4587-4809
ISSN: 2332-0737
+44-20-4587-4809
Abdullah Al Mutery
University of Sharjah, UAE
Keynote: Curr Synthetic Sys Biol
Vesicular monoamine transporters (VMATs) are an important target for biological research in neuropsychiatric disorders. Recent studies indicated that VMAT1 is expressed in the brain, thus making transporter plausible candidate genes for neuropsychiatric disorders. Furthermore, several recent genetic case-control studies have documented an association between common missense variations in the VMAT1 gene and susceptibility to bipolar disorder and schizophrenia. Until now, there are no reports of VMAT1 allele frequencies in Emirati population. Hence, the aim of the present work was to study VMAT1 genetic polymorphism in healthy Emirati population. Saliva samples were collected from 248 healthy Emiratis and genotyping was done for rs2270641 by PCR-RFLP and rs2270637 and rs1390938 by Taqman assay. The minor allele frequencies of rs2270641, rs2270637 and rs1390938 were 0.48, 0.20 and 0.18, respectively, which were compared with that of available HapMap population data. In conclusion, the present study is first of its kind in Emirati population that established the allele and genotype frequency for various VMAT1 alleles which can be exploited to design future studies on the genetic association of neuropsychiatry disorders. Recent Publications 1. Skinner B M, Al Mutery A, Smith D, V�?¶lker M, Hojjat N, Raja S, Trim S, Houde P, Boecklen W J, Griffin D K (2104) Global patterns of apparent copy number variation in birds revealed by cross-species comparative genomic hybridization. Chromosome Res.; 22(1): 59-70. 2. Lithgow P E, O'Connor R, Smith D, Fonseka G, Al Mutery A, Rathje C, Frodsham R, O'Brien P, Kasai F, Ferguson-Smith M A, Skinner B M, Griffin D K (2014) Novel tools for characterizing inter and intra chromosomal rearrangements in avian microchromosomes. Chromosome Res.; 22(1): 85-97.
Abdullah Al Mutery holds PhD in Genetics and since 2014; he is working as a Faculty Member in Applied Biology Department, College of Science at University Sharjah. He has interest in human mutation and animal genomic comparative evolution studies.