Journal of Proteomics & Bioinformatics
Open Access

Gastric Endoscopic Submucosal Dissection (ESD) as a treatment for early neoplasia and for accurate staging of early cancers in UK Caucasian population

Joint Event on 9^th World Biomarkers Congress & 20^th International Conference on Pharmaceutical Biotechnology

December 07-09, 2017 | Madrid, Spain

M Davenport, Aisha Sooltangos, S McGrath, J Vickers, S Senapati, K Akhtar, R George and Yeng Ang

Salford Royal NHS Foundation Trust, UK
Pennine Acute NHS Trust - Salford Royal NHS foundation Trust, UK
Salford Royal NHS Foundation Trust, UK

Scientific Tracks Abstracts: J Proteomics Bioinform

Abstract :

Aim: To investigate the efficacy of Endoscopic Submucosal Dissection (ESD) at diagnosing and treating superficial neoplastic lesions of the stomach in a Caucasian population. Methods: Data of Caucasian patients treated with or considered for ESD at a tertiary referral center were retrieved for a 3-year period. Primary outcomes were curative resection (CR), which was defined as ESD resections with clear margins and an absence of lymphovascular invasion, poor differentiation and submucosal involvement on histology. Secondary outcomes were reversal of dysplasia at 12 months follow-up and/or at the latest follow up. Change in histological diagnosis pre and post ESD was recorded. Results: Twenty four patients were identified with intention to treat. Nineteen patients were considered eligible, and ESD was attempted on 25 lesions, 4 of which failed and were aborted. Out of 21 ESD performed, en-bloc resection was achieved in 71.4% of cases. Resection was considered complete on endoscopy in 90.5% of cases compared to only 38.1% on histology. Six resections were considered curative (28%), 5 non-curative (48%) and 10 indefinite (24%). ESD changed the histological diagnosis in 66.6% of cases post ESD. Endoscopic follow-up in the indefinite group and CR group showed that 50% and 80% of patients were clear of dysplasia at the latest follow-up respectively; 2 cases of recurrence were observed in the indefinite group and survival rate for the entire cohort was 91.7%. Conclusion: This study provides evidence for the efficacy of ESD as a therapeutic and diagnostic intervention in Caucasian populations and supports its application in the UK.

Biography :

M Davenport is a Foundation Year 2 Doctor at Salford Royal Hospital, Manchester, UK. He is presenting on behalf of a team headed by Dr. Yeng S Ang, MD, FRCP, Consultant Gastroenterologist, Salford Royal University Hospital, UK. Honorary Reader, University of Manchester, Manchester, UK