Journal of Pharmaceutical Care & Health Systems
Open Access
ISSN: 2376-0419
+44 1300 500008
ISSN: 2376-0419
+44 1300 500008
Riyaz Ahmad Rather
Post Graduate Institute of Medical Education and Research, India
Posters-Accepted Abstracts: J Pharma Care Health Sys
Endophytes are the endosymbionts which colonizes the plant tissue and live inside the host plant without causing any apparent damage. It is believed that most of the plants harbor fungal endophytes which produce wide range of secondary metabolites. The secondary metabolites produced by these endophytes have prospective applications in pharmaceutical industry. Some of the endophyte derived bioactive compouns like antibiotics (xiamycins, munumbicins, pseudomycins, ecomycins or cephalosporins) have emerged as the most efficative drugs. Apart from these antibiotics the diverse biosimilars produced by these fungal endophytes have anti-viral compounds, anti-cancer-agents, anti-neoplastic agents, insecticidal products, anti-diabetic agents, anti-malarial agents, anti-fungal agents, cytotoxic agents, immuno-suppressive compounds as well as antioxidant activities. The world��?s first billion-dollar anticancer-drug, paclitaxel (taxol) is an outstanding example of a natural product from Yew tree, Taxus wallachiana and later same drug was reported to produce by endophytic fungus Pestalotiopsis microspore. Tolypocladium inflatum, endophytic fungus from herb Asparagus racemosus, produce classical immuno-suppressive cyclosporine, which had a positive effect on immunomodulation reactions. These endophytes apart from proving secret machinery for synthesis of pharmaceutical agents have produced novel compounds mimicking repellants and toxicants like heptelidic acid, rugulosine, formilonine and paxiline analogous that could help in biocontrol of insect and pests. Due to huge diversity of fungal endophytes, they seem to be an alternate source of bioactive natural products with possible applications in pharmaceutical industry. Hence fungal entophytes should be exploited as a source of new antibiotics against susceptible and resistant forms of micro-organisms is the most important and promising.
Email: farhan.rizu@gmail.com