Journal of Pharmaceutical Care & Health Systems
Open Access
ISSN: 2376-0419
ISSN: 2376-0419
M Srujan Kumar
Posters-Accepted Abstracts: J Pharma Care Health Sys
The transdermal route of drug delivery has gained great interest of pharmaceutical research, as it circumvents number of problems associated with oral route of drug administration. The major barrier in transdermal delivery of drug is the skin intrinsic barrier, the stratum corneum, the outermost layer of the skin that offers the principal barrier for diffusion of drug. Recently, various strategies have been used to improve the transdermal delivery of drug. Among these strategies Liposomes are known to have considerable potential as drug carriers such as liposomal suspension, freeze dried and cream-based systems among many other liposomal formulations. Sumatriptan Succinate is an agonist for a vascular 5-hydroxytryptamine receptor subtype (probably a member of the 5-HT1D family), having an elimination half life of 2.5 Hours, its maximum daily dose is 200 mg orally and oral bioavailability is 15%. The present study is aimed to fabricate Sumatriptan Succinate �??lipo-drug-in-adhesive�?� patch system, using liposome based carrier for increased permeability of Sumatriptan Succinate through skin pores. Transfersomes as ultra-deformable liposomes based on phosphatidyl choline as vesicle forming component, surfactants like sodium cholate, sodium deoxy cholate, Tween-80 and Span-80 for providing flexibility were prepared by hand shaken method, Sonication, Free Thaw method, Rotary shaking method and further optimized in a acrylic patch system for effective adhesion. The role of Transfersome on drug release characteristics of transdermal drug-in-adhesive patch in relation to the peel strength and tack value of the whole acrylic adhesive patch is studied and reported.