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Deep Shikha Sharma
Lovely Professional University, India
Posters & Accepted Abstracts: J Develop Drugs Res
Nanoparticles act as a promising system for targeted delivery of drugs and as an effective route of drug administration. In this study, polysorbate 80 coated nanoparticles of serratiopeptidase were formulated and aimed for the treatment of blood clots in brain. Serratiopeptidase exerts effective activity against blood clotting and has ability to dissolve nonliving tissues, blood clots, cysts and atherosclerotic clots. Different nanoparticle formulations of serratiopeptidase were prepared with different concentrations of chitosan and tripolyphosphate using ionic gelation method. The nanoparticles were coated using polysorbate 80 and were characterized and evaluated for different parameters such as particle size, entrapment efficiency, zeta potential and transmission electron microscopy. The in vitro drug release of prepared nanoparticles was studied in phosphate buffer (pH 7.4). The results indicated that the developed nanoparticle formulation could be established as a promising carrier for active targeting into brain to dissolve blood clots.
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