Journal of Pharmaceutical Care & Health Systems
Open Access
ISSN: 2376-0419
+44 1300 500008
ISSN: 2376-0419
+44 1300 500008
Mina Abbasnia
Hamedan university of medical science, Iran
Posters & Accepted Abstracts: J Pharma Care Health Sys
Tramadol Hydrochloride is a synthetic Opioid analgesic, with a suitable effect on cancer and post-op pains. Its addiction and short half-life make it hard to use. Its main metabolite (O-des methyl Tramadol) is a pure agonist of μ receptors and the cause of addiction. Transdermal Drug Delivery System (TDDS), is a delivery system that can control the drug release perfectly and it has no First Pass Metabolism (FPM) and is non-invasive. In order to modify this delivery system features, Solid Lipid Nanoparticles (SLNs) can be used as the carrier of choice. Tramadol Hydrochloride loaded SLNs were prepared using Double Emulsification- Solvent Evaporation technique and a Central-Composite design, based on two independent variables (lipid/soy lecithin ratio and the amount of drug), which used to reduce the number of required experiments. In order to examine the experimental design method, Polydispersity index (PdI), particle size, Zeta potential, Entrapment and Loading efficiency and In-vitro release studies were determined using a Zetasizer NanoZS and HPLC system. Also, the microscopic pictures of the particles were taken using a Transmission Electronic Microscope. The optimum results for Tramadol HCl loaded SLNs were as follows: Size: 197 nm, PdI: 0.21, Zeta: -19.8, EE: %89.4, LE: %9.74. Also, up to 30 % of incorporating drug was released from optimized SLNs in the initial period of 6 h and up to 40 % of the drug was released in a period of 24 h, and according to these results, the SLNs formulation follows Fickian diffusion. Also, the TEM images showed a nearly spherical shape of the particles. As a result, there was no significant difference between calculated and measured data, Tramadol HCl loaded SLNs can be used as a local analgesic. Although Further experiments (specially pharmaceutical and pharmacological) will be needed in order to use this product clinically.