Journal of Thyroid Disorders & Therapy
Open Access
ISSN: 2167-7948
+44 1300 500008
ISSN: 2167-7948
+44 1300 500008
Gyan Chand
Sanjay Gandhi Post Graduate Institute of Medical Sciences, India
Posters & Accepted Abstracts: Thyroid Disorders Ther
Introduction: Follicular Variant of Papillary Thyroid Carcinoma (FVPTC) is being increasingly diagnosed in recent years, however little is known about its histopathological and clinical behavior. Aim: The purpose of this study is to determine clinical characteristics of FVPTC and to compare it with classical Papillary Thyroid Carcinoma (cPTC). Methods: We prospectively analyzed the retrospectively collected data of 182 PTC patients treated between 2009 and 2012. Two pathologists, who were blinded of the clinical and previous histopathology report, individually reviewed the slides. Statistical analysis was done using SPSS version 17.0 and non parametric tests were used to compare FVPTC and cPTC. Results: There were 35 cases of follicular variant of PTC (FVPTC) and 147 cases of classic PTC (cPTC). On comparison, FVPTC presented more commonly in males and as multinodular goiters and cPTC had more incidence of LN metastasis. Compared to cPTC, FVPTC had histopathologically higher incidence of capsular invasion and extraThyroidal extension and distant metastasis (p<0.001). FVPTC patients had bone as the more common site of metastasis, whereas cPTC patients had pulmonary as the site of metastasis. Conclusions: FVPTC is a common variant of PTC and has unique clinical behavior. Inspite of there being variations in clinical behavior between FVPTC and cPTC, the long term outcome of FVPTC patients remains similar to that of cPTC.
Email: drgyanchandpgi@gmail.com