Journal of Perioperative & Critical Intensive Care Nursing
Open Access
ISSN: 2471-9870
ISSN: 2471-9870
Dhierin R. Jagdewsing
Second Affiliated Hospital of Dalian Medical University, China
Scientific Tracks Abstracts: J Perioper Crit Intensive Care Nurs
Objective: Phyllodes tumor (PT) is a variant of f ibroepithelial proliferations of the breast, histologically demonstrating a leaf-like pattern. The WHO has categorized PTs as benign, borderline, or malignant based on their histological characteristics. The objective of this paper is to assess the clinicopathological factors with malignancy in PT of the breast. Method: Medical records of 101 diagnosed PT patients in the Second Affiliated Hospital of Dalian Medical University between 2008 and 2023 were reviewed. Information on clinical presentation and histopathological findings of the lesions were retrieved from patient files and/or histological reports, respectively. Results: Of the 101 patients, all were female and had a mean age of 44.35 ± 14.14 years and mean tumor size of 8.3 ± 5.8 cm The distribution for the histological type was benign (n = 54, 53.4%), borderline (n = 36, 35.6%) and malignant (n = 11, 10.8%). Most benign PTs were observed in younger patients, while borderline and malignant PTs involved elderly patients, with a mean age of 47.56 ± 11.86 years for borderline PT and a mean age of 46.55 ± 11.62 years for malignant PT. Benign PTs had a mean size of 5.58 ± 2.29 cm, while those of borderline andmalignant were larger, with a mean size of 10.58 ± 6.79 cm and 14.90 ± 6.44 cm, respectively. Malignant PTs had higher lactate dehydrogenase (LDH) levels of 232 ± 91.5 U/L compared to borderline PTs, 177.9 ± 19.9 U/L, and benign PTs, 177.6 ± 39.9U/L. The course of the disease of the malignant PT group was slightly longer (436.9 ± 391.3 weeks) than that of the benign (44.17 ± 71.54 weeks) and borderline (54.33 ± 94.33 weeks). In histopathology, necrosis was observed only in malignant PTs (81.8%), and severe stromal atypia was seen in 72.7% of malignant cases. The mitotic count was highest in malignant PTs at 13.18 ± 4.43 HPF as compared to benign 3.52 ± 2.97 HPF and borderline PTs at 7.28 ± 2.21 HPF. Conclusion: Benign PTs were more common in this study than malignant or borderline PTs. There was a highly significant correlation between patient age, tumor size, LDH, and disease progression in all subtypes of PT. This analysis showed that malignant PTs were larger and observed in older patients with higher LDH and with a longer duration of the disease. Other factors, in addition to histological properties, are useful in determining PT behavior and management. More studies at an advanced level of evidence in the form of randomized trials are required when developing a risk classification for PT based on patient age, tumor size, and LDH.
Dhierin Roman Jagdewsing, born in Suriname, is a junior surgeon and researcher specializing in general surgery. He holds a Master of Medicine in General Surgery and an MBBS from Dalian Medical University, China. Dhierin Has extensive clinical experience in general surgery procedures, including colectomy and mastectomy, and is actively involved in research onsurgical outcomes and cancer pathology. A recipient of multiple Chinese Government Schol arship, he is committed to advancing evidence-based care in oncology and surgery.