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R A Youness, M A Rahmoon, R A Assal, A I Gomaa, I Waked, H M El-Tayebi and A I Abdelaziz
German University in Cairo, Egypt
Posters & Accepted Abstracts: J Proteomics Bioinform
Hepatocellular Carcinoma (HCC) is one of the most violent prevalent neoplasms in Egypt which is not amendable for conventional therapeutic modalities. Recently, Immuno-therapeutic approaches have been probed as a promising strategy to combat malignancies. As a cornerstone of innate immune system, Natural Killer (NK) cells play an essential role in the fight against Tumor development. In response, HCC have evolved mechanisms to escape control from NK cells, such as reducing NK cells cytolytic activity and recognition ability. Interestingly, The role of IGF-1/IGF-1R and downstream signalling cascades has been recently emerged as important modulators of normal NK cells cytotoxicity adding to its indisputable role in HCC progression. Therefore, our research group has recently focused on untangling the molecular signalling pathways underlying the impaired functionality of peripheral NK cells derived from HCC patients and to epigenetically modulate those defects using miR-486-5p in an attempt of improving their cytotoxic potential.